Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 3750..4330 Replicon plasmid phvKP12-F
Accession NZ_CP103321
Organism Klebsiella pneumoniae strain hvKP12

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag NXZ72_RS30360 Protein ID WP_071177730.1
Coordinates 4016..4330 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag NXZ72_RS30355 Protein ID WP_000093040.1
Coordinates 3750..4028 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXZ72_RS30335 (NXZ72_30335) 191..1678 - 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -
NXZ72_RS30340 (NXZ72_30340) 2323..2568 + 246 WP_032440458.1 hypothetical protein -
NXZ72_RS30345 (NXZ72_30345) 2842..3213 + 372 WP_001237044.1 cell envelope integrity protein TolA -
NXZ72_RS30350 (NXZ72_30350) 3210..3575 + 366 WP_072354022.1 TonB family protein -
NXZ72_RS30355 (NXZ72_30355) 3750..4028 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
NXZ72_RS30360 (NXZ72_30360) 4016..4330 + 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NXZ72_RS30365 (NXZ72_30365) 4494..4922 + 429 WP_001140599.1 hypothetical protein -
NXZ72_RS30370 (NXZ72_30370) 4948..5127 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
NXZ72_RS30375 (NXZ72_30375) 5154..5684 - 531 WP_071177729.1 hypothetical protein -
NXZ72_RS30380 (NXZ72_30380) 5691..6422 - 732 WP_071177728.1 MobC family replication-relaxation protein -
NXZ72_RS30385 (NXZ72_30385) 6422..8386 - 1965 WP_071177727.1 TraM recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11970 11970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T254930 WP_071177730.1 NZ_CP103321:4016-4330 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT254930 WP_000093040.1 NZ_CP103321:3750-4028 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References