Detailed information of TA system TA025493

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 322846..323572
• Replicon: chromosome
• Accession: NC_015761
• Organism: Salmonella bongori NCTC 12419

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: A0A248KBV8
• Locus tag: SBG_RS01445
• Protein ID: WP_001194750.1
• Coordinates: 323231..323572 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A248KCL1
• Locus tag: SBG_RS01440
• Protein ID: WP_000380487.1
• Coordinates: 322846..323187 (+)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBG_RS01395	318062..318367	+	306	WP_000227087.1	hypothetical protein	-
SBG_RS01400	318720..319434	+	715	Protein_271	WYL domain-containing protein	-
SBG_RS22890	319507..319653	+	147	WP_023892166.1	hypothetical protein	-
SBG_RS01410	319670..319873	+	204	WP_000508162.1	hypothetical protein	-
SBG_RS21255	319938..320852	+	915	WP_000797249.1	hypothetical protein	-
SBG_RS01420	320927..321172	+	246	WP_000082136.1	DUF905 domain-containing protein	-
SBG_RS01425	321274..322092	+	819	WP_001234407.1	DUF945 domain-containing protein	-
SBG_RS01430	322105..322605	+	501	WP_001090292.1	DNA repair protein RadC	-
SBG_RS01435	322602..322823	+	222	WP_000691988.1	DUF987 family protein	-
SBG_RS01440	322846..323187	+	342	WP_000380487.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
SBG_RS01445	323231..323572	+	342	WP_001194750.1	TA system toxin CbtA family protein	Toxin
SBG_RS01450	323688..324521	+	834	WP_001192753.1	DUF4942 domain-containing protein	-
SBG_RS01455	324622..325269	+	648	WP_000026701.1	DUF4433 domain-containing protein	-
SBG_RS01460	325283..326335	+	1053	WP_000575274.1	macro domain-containing protein	-
SBG_RS01465	326373..327692	-	1320	WP_001218450.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	306683..348167	41484

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (2-109)

Antitoxin

• Antitoxin CbeA (11-109)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 13116.01 Da
• Isoelectric Point: 9.7617

>T25493 WP_001194750.1 NC_015761:323231-323572 [Salmonella bongori NCTC 12419]
MQTQYNHPHRATPSQPSPVEIWQKLLTHLLAKHYGLELSDTPFSVEKVIQEHIDAGITLANAVNFIVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRRQRYLAAH

Nucleotide

• Length: 342 bp

>T25493 NC_015761:323231-323572 [Salmonella bongori NCTC 12419]
ATGCAAACCCAATACAACCACCCACACCGGGCGACCCCGTCACAGCCGTCGCCTGTCGAAATCTGGCAAAAACTGCTGAC
CCATTTACTGGCTAAACATTATGGGCTCGAACTCAGTGACACGCCGTTTAGCGTAGAGAAGGTGATTCAGGAACACATTG
ACGCCGGTATCACGCTGGCTAATGCCGTGAACTTTATTGTAGAGAAATACGAGCTGGTTCGTATCGATCGCAAGGGATTT
AGCTGGCAGGAACAATCACCCTATCTTCGGGCTGTAGACATTCTGCGGGCGCGACAGGCTACGGGTCTGTTGCGACGTCA
ACGCTATCTCGCGGCACACTGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12770.65 Da
• Isoelectric Point: 9.4771

>AT25493 WP_000380487.1 NC_015761:322846-323187 [Salmonella bongori NCTC 12419]
MDTNETQSTPVWGLRNDVFPSFGARLVQEGNHLHYLADRAGIYGEFTPAQLKTLNIVFPMFIKRMEVALRTGALNPREAR
RFTTALRGIICEADTRGSFGYVYLSLYPTVVKN

Nucleotide

• Length: 342 bp

>AT25493 NC_015761:322846-323187 [Salmonella bongori NCTC 12419]
ATGGACACAAATGAAACACAATCCACGCCAGTATGGGGACTACGGAACGATGTCTTCCCGTCATTTGGCGCCCGGTTAGT
TCAGGAAGGTAATCACCTGCACTATCTGGCTGACCGGGCGGGTATTTACGGTGAATTTACCCCGGCGCAACTAAAGACTC
TGAATATCGTATTTCCAATGTTTATTAAACGCATGGAGGTCGCTTTACGCACTGGCGCACTCAATCCGCGCGAAGCCAGA
CGCTTTACGACTGCACTCCGGGGCATAATCTGCGAAGCCGACACTCGCGGATCGTTCGGTTACGTTTATCTTTCGCTTTA
CCCAACCGTCGTTAAAAACTGA

Structures

Toxin

• AlphaFold DB: A0A248KBV8

Antitoxin

• AlphaFold DB: A0A248KCL1