254927

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 37014..37657 Replicon plasmid phvKP12-KPC
Accession NZ_CP103319
Organism Klebsiella pneumoniae strain hvKP12

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag NXZ72_RS29670 Protein ID WP_001044770.1
Coordinates 37014..37430 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag NXZ72_RS29675 Protein ID WP_001261282.1
Coordinates 37427..37657 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXZ72_RS29650 (33117) 33117..33389 - 273 Protein_41 transposase -
NXZ72_RS29660 (34371) 34371..35393 - 1023 WP_000361404.1 helicase UvrD -
NXZ72_RS29665 (35378) 35378..36940 - 1563 WP_004206609.1 AAA family ATPase -
NXZ72_RS29670 (37014) 37014..37430 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
NXZ72_RS29675 (37427) 37427..37657 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NXZ72_RS29680 (37614) 37614..38075 + 462 WP_014343465.1 hypothetical protein -
NXZ72_RS29685 (38236) 38236..39180 + 945 WP_011977810.1 hypothetical protein -
NXZ72_RS29690 (39217) 39217..39609 + 393 WP_011977811.1 hypothetical protein -
NXZ72_RS29695 (39667) 39667..40188 + 522 WP_013214008.1 hypothetical protein -
NXZ72_RS29700 (40234) 40234..40437 + 204 WP_011977813.1 hypothetical protein -
NXZ72_RS29705 (40467) 40467..41471 + 1005 WP_011977814.1 hypothetical protein -
NXZ72_RS29710 (41655) 41655..42434 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-65 / blaSHV-12 / blaKPC-2 - 1..83447 83447


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T254927 WP_001044770.1 NZ_CP103319:c37430-37014 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT254927 WP_001261282.1 NZ_CP103319:c37657-37427 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References