254925

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 63349..64259 Replicon plasmid phvKP12-VIR
Accession NZ_CP103316
Organism Klebsiella pneumoniae strain hvKP12

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag NXZ72_RS27560 Protein ID WP_004026354.1
Coordinates 63789..64259 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag NXZ72_RS27555 Protein ID WP_004026357.1
Coordinates 63349..63792 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXZ72_RS27525 (NXZ72_27525) 59225..59626 - 402 WP_214588034.1 LuxR C-terminal-related transcriptional regulator -
NXZ72_RS27530 (NXZ72_27530) 59979..60101 - 123 WP_213034833.1 mucoid phenotype synthesis protein RmpD -
NXZ72_RS27535 (NXZ72_27535) 60157..60789 - 633 WP_004213609.1 mucoid phenotype regulator RmpA -
NXZ72_RS27540 (NXZ72_27540) 61331..61489 + 159 Protein_74 SAM-dependent methyltransferase -
NXZ72_RS27545 (NXZ72_27545) 61559..62539 + 981 WP_000019473.1 IS5-like element ISKpn26 family transposase -
NXZ72_RS27550 (NXZ72_27550) 62745..63248 + 504 Protein_76 DUF4113 domain-containing protein -
NXZ72_RS27555 (NXZ72_27555) 63349..63792 + 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
NXZ72_RS27560 (NXZ72_27560) 63789..64259 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
NXZ72_RS27565 (NXZ72_27565) 64408..65105 + 698 WP_223175001.1 IS1-like element IS1A family transposase -
NXZ72_RS27570 (NXZ72_27570) 66491..67141 - 651 WP_068893702.1 DUF1173 family protein -
NXZ72_RS27575 (NXZ72_27575) 67174..67440 - 267 WP_223175074.1 DUF1173 family protein -
NXZ72_RS27580 (NXZ72_27580) 67618..68112 + 495 WP_004212794.1 thermonuclease family protein -
NXZ72_RS27585 (NXZ72_27585) 68449..68847 + 399 WP_004212796.1 H-NS family nucleoid-associated regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA2 / iutA / iucD / iucC / iucB / iucA / iroN / rmpA 1..225067 225067
- inside IScluster/Tn - - 61559..72156 10597


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T254925 WP_004026354.1 NZ_CP103316:63789-64259 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT254925 WP_004026357.1 NZ_CP103316:63349-63792 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References