254923

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5412935..5413560 Replicon chromosome
Accession NZ_CP103315
Organism Klebsiella pneumoniae strain hvKP12

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag NXZ72_RS26805 Protein ID WP_002882817.1
Coordinates 5412935..5413318 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag NXZ72_RS26810 Protein ID WP_004150355.1
Coordinates 5413318..5413560 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXZ72_RS26790 (NXZ72_26790) 5410301..5411203 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
NXZ72_RS26795 (NXZ72_26795) 5411200..5411835 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
NXZ72_RS26800 (NXZ72_26800) 5411832..5412761 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
NXZ72_RS26805 (NXZ72_26805) 5412935..5413318 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
NXZ72_RS26810 (NXZ72_26810) 5413318..5413560 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
NXZ72_RS26815 (NXZ72_26815) 5413765..5414682 + 918 WP_002882812.1 alpha/beta hydrolase -
NXZ72_RS26820 (NXZ72_26820) 5414696..5415637 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
NXZ72_RS26825 (NXZ72_26825) 5415682..5416119 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
NXZ72_RS26830 (NXZ72_26830) 5416116..5416976 - 861 WP_002882807.1 virulence factor BrkB family protein -
NXZ72_RS26835 (NXZ72_26835) 5416970..5417569 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-112)

Antitoxin

(16-47)


Sequences


Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T254923 WP_002882817.1 NZ_CP103315:c5413318-5412935 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp


Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT254923 WP_004150355.1 NZ_CP103315:c5413560-5413318 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References