Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5088884..5090565 Replicon chromosome
Accession NZ_CP103315
Organism Klebsiella pneumoniae strain hvKP12

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NXZ72_RS25300 Protein ID WP_002885155.1
Coordinates 5088884..5089801 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag NXZ72_RS25305 Protein ID WP_004151732.1
Coordinates 5089807..5090565 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXZ72_RS25280 (NXZ72_25280) 5084190..5085710 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NXZ72_RS25285 (NXZ72_25285) 5085707..5086705 + 999 WP_002885172.1 ribose ABC transporter permease -
NXZ72_RS25290 (NXZ72_25290) 5086736..5087677 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NXZ72_RS25295 (NXZ72_25295) 5087752..5088759 + 1008 WP_004151731.1 carbohydrate kinase family protein -
NXZ72_RS25300 (NXZ72_25300) 5088884..5089801 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NXZ72_RS25305 (NXZ72_25305) 5089807..5090565 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NXZ72_RS25310 (NXZ72_25310) 5090651..5091379 - 729 WP_002885152.1 response regulator transcription factor -
NXZ72_RS25315 (NXZ72_25315) 5091652..5093799 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
NXZ72_RS25320 (NXZ72_25320) 5094029..5094715 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T254922 WP_002885155.1 NZ_CP103315:c5089801-5088884 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT254922 WP_004151732.1 NZ_CP103315:c5090565-5089807 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References