Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4932700..4933216 Replicon chromosome
Accession NZ_CP103315
Organism Klebsiella pneumoniae strain hvKP12

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NXZ72_RS24500 Protein ID WP_002886902.1
Coordinates 4932700..4932984 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NXZ72_RS24505 Protein ID WP_002886901.1
Coordinates 4932974..4933216 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXZ72_RS24475 (NXZ72_24475) 4928184..4928447 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NXZ72_RS24480 (NXZ72_24480) 4928577..4928750 + 174 WP_002886906.1 hypothetical protein -
NXZ72_RS24485 (NXZ72_24485) 4928753..4929496 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NXZ72_RS24490 (NXZ72_24490) 4929853..4931991 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
NXZ72_RS24495 (NXZ72_24495) 4932232..4932696 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NXZ72_RS24500 (NXZ72_24500) 4932700..4932984 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NXZ72_RS24505 (NXZ72_24505) 4932974..4933216 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NXZ72_RS24510 (NXZ72_24510) 4933294..4935204 - 1911 WP_004152270.1 PRD domain-containing protein -
NXZ72_RS24515 (NXZ72_24515) 4935227..4936381 - 1155 WP_002886900.1 lactonase family protein -
NXZ72_RS24520 (NXZ72_24520) 4936447..4937187 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T254921 WP_002886902.1 NZ_CP103315:c4932984-4932700 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT254921 WP_002886901.1 NZ_CP103315:c4933216-4932974 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References