Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2749611..2751199 Replicon chromosome
Accession NZ_CP103315
Organism Klebsiella pneumoniae strain hvKP12

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NXZ72_RS13650 Protein ID WP_259037751.1
Coordinates 2749611..2750933 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NXZ72_RS13655 Protein ID WP_002904790.1
Coordinates 2750933..2751199 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXZ72_RS13635 (NXZ72_13635) 2744676..2747177 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
NXZ72_RS13640 (NXZ72_13640) 2747165..2748169 + 1005 WP_004199852.1 fimbrial protein -
NXZ72_RS13645 (NXZ72_13645) 2748302..2749594 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NXZ72_RS13650 (NXZ72_13650) 2749611..2750933 - 1323 WP_259037751.1 type II toxin-antitoxin system HipA family toxin Toxin
NXZ72_RS13655 (NXZ72_13655) 2750933..2751199 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NXZ72_RS13660 (NXZ72_13660) 2751465..2751791 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NXZ72_RS13665 (NXZ72_13665) 2751788..2752288 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NXZ72_RS13670 (NXZ72_13670) 2752266..2753645 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
NXZ72_RS13675 (NXZ72_13675) 2753991..2755145 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NXZ72_RS13680 (NXZ72_13680) 2755126..2756049 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49146.47 Da        Isoelectric Point: 7.2487

>T254918 WP_259037751.1 NZ_CP103315:c2750933-2749611 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRAMAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT254918 WP_002904790.1 NZ_CP103315:c2751199-2750933 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References