Detailed information of TA system TA025491

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 815349..815808
• Replicon: chromosome
• Accession: NC_015760
• Organism: Streptococcus salivarius CCHSS3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F8LI54
• Locus tag: SALIVB_RS03550
• Protein ID: WP_013990357.1
• Coordinates: 815554..815808 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F8LI53
• Locus tag: SALIVB_RS03545
• Protein ID: WP_013990356.1
• Coordinates: 815349..815564 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SALIVB_RS03535	813200..814284	+	1085	Protein_639	hypothetical protein	-
SALIVB_RS03540	814374..815216	+	843	WP_013990355.1	aldo/keto reductase	-
SALIVB_RS03545	815349..815564	+	216	WP_013990356.1	hypothetical protein	Antitoxin
SALIVB_RS03550	815554..815808	+	255	WP_013990357.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SALIVB_RS03555	815954..816640	+	687	WP_013990358.1	DUF1275 domain-containing protein	-
SALIVB_RS03560	816734..817366	+	633	WP_013990359.1	nitroreductase family protein	-
SALIVB_RS03565	817560..818852	+	1293	WP_013990360.1	PTS sugar transporter subunit IIC	-
SALIVB_RS03570	818839..819702	+	864	WP_013990361.1	alpha/beta hydrolase	-
SALIVB_RS03575	819887..820336	+	450	WP_013990362.1	Rrf2 family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-57)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9862.61 Da
• Isoelectric Point: 11.1183

>T25491 WP_013990357.1 NC_015760:815554-815808 [Streptococcus salivarius CCHSS3]
MTYKIVPTPKFAKSFKKLDPFVRKQIKSYLNRVTDNPRAKGKALVANRTGQWRYRIGAYRVIVNIQDNELIILALEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T25491 NC_015760:815554-815808 [Streptococcus salivarius CCHSS3]
ATGACCTATAAGATAGTACCAACCCCAAAATTTGCCAAAAGTTTTAAAAAGTTGGACCCTTTTGTCAGGAAACAAATTAA
GTCTTATCTCAATCGTGTCACAGATAATCCAAGAGCCAAGGGTAAGGCCTTAGTTGCCAATCGAACTGGACAATGGCGCT
ATCGTATTGGTGCCTATCGTGTTATTGTCAATATTCAGGACAATGAACTAATCATACTTGCCCTCGAAGTCGGTCATAGA
CGTGATATCTATTAG

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8016.98 Da
• Isoelectric Point: 3.8852

>AT25491 WP_013990356.1 NC_015760:815349-815564 [Streptococcus salivarius CCHSS3]
MTTITLKVSEADKKFMQAIAKFEGVSLSELIRTKTLDAIEDEYDARVADLALAEYEDYLENGGEVLNWDDL

Nucleotide

• Length: 216 bp

>AT25491 NC_015760:815349-815564 [Streptococcus salivarius CCHSS3]
ATGACAACAATTACATTGAAGGTTTCAGAAGCAGATAAGAAATTCATGCAGGCAATTGCGAAATTTGAAGGCGTATCCTT
GTCAGAATTAATTCGTACCAAGACTTTAGACGCCATTGAGGATGAATATGATGCTAGAGTAGCCGATTTAGCATTAGCAG
AATATGAAGACTATCTTGAAAACGGTGGGGAGGTGCTAAATTGGGATGACCTATAA

Structures

Toxin

• AlphaFold DB: F8LI54

Antitoxin

• AlphaFold DB: F8LI53