Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 3654455..3655963 Replicon chromosome
Accession NZ_CP103307
Organism Pseudomonas aeruginosa strain PLL01

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag NX763_RS16975 Protein ID WP_003119682.1
Coordinates 3655376..3655963 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9HYX2
Locus tag NX763_RS16970 Protein ID WP_003115566.1
Coordinates 3654455..3655309 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NX763_RS16955 (NX763_16955) 3649874..3650083 + 210 WP_003115568.1 cold-shock protein -
NX763_RS16960 (NX763_16960) 3650144..3652018 - 1875 WP_003091605.1 MFS transporter -
NX763_RS16965 (NX763_16965) 3652193..3654358 - 2166 WP_003115567.1 TonB-dependent receptor family protein -
NX763_RS16970 (NX763_16970) 3654455..3655309 - 855 WP_003115566.1 AraC family transcriptional regulator Antitoxin
NX763_RS16975 (NX763_16975) 3655376..3655963 - 588 WP_003119682.1 GNAT family protein Toxin
NX763_RS16980 (NX763_16980) 3656229..3659708 + 3480 WP_003114080.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T254904 WP_003119682.1 NZ_CP103307:c3655963-3655376 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31933.23 Da        Isoelectric Point: 7.3276

>AT254904 WP_003115566.1 NZ_CP103307:c3655309-3654455 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB Q9HYX2

References