Detailed information of TA system TA025490

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 45089..45689
• Replicon: chromosome
• Accession: NC_015760
• Organism: Streptococcus salivarius CCHSS3

Toxin (Protein)

• Gene name: parE
• Uniprot ID: F8LGD0
• Locus tag: SALIVB_RS00280
• Protein ID: WP_013989897.1
• Coordinates: 45360..45689 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: F8LGC9
• Locus tag: SALIVB_RS00275
• Protein ID: WP_002889575.1
• Coordinates: 45089..45376 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SALIVB_RS10345	41474..42727	+	1254	WP_172633786.1	AAA family ATPase	-
SALIVB_RS00265	42729..43982	+	1254	WP_041817175.1	protein kinase	-
SALIVB_RS00270	44141..44980	-	840	WP_013989896.1	CHAP domain-containing protein	-
SALIVB_RS00275	45089..45376	+	288	WP_002889575.1	hypothetical protein	Antitoxin
SALIVB_RS00280	45360..45689	+	330	WP_013989897.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SALIVB_RS00285	45961..47223	+	1263	WP_013989898.1	phosphoribosylamine--glycine ligase	-
SALIVB_RS00290	47423..47914	+	492	WP_013989899.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
SALIVB_RS00295	47901..48992	+	1092	WP_013989900.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
SALIVB_RS00300	48993..49943	+	951	WP_013989901.1	NAD(P)-binding domain-containing protein	-
SALIVB_RS00305	49952..50179	+	228	WP_013989902.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12662.64 Da
• Isoelectric Point: 10.2062

>T25490 WP_013989897.1 NC_015760:45360-45689 [Streptococcus salivarius CCHSS3]
MNTTYSLSLTKRARSSLRSIYDYIRDVLSNETAAKKIVPKLLQGMESLKTFPEAGFNADQRYGKRINDTFETRALVVKRY
VILYFIDESRKEIVVSHIFSSKSDYIKLL

Nucleotide

• Length: 330 bp

>T25490 NC_015760:45360-45689 [Streptococcus salivarius CCHSS3]
ATGAATACAACCTATAGTCTTTCACTCACTAAGCGTGCTCGCTCTTCTTTGAGAAGTATATATGACTACATTCGTGATGT
ACTTTCTAATGAAACTGCTGCCAAGAAGATAGTTCCGAAGCTTTTGCAAGGAATGGAAAGTTTGAAGACTTTTCCTGAGG
CTGGTTTTAATGCAGATCAACGTTATGGTAAAAGAATCAATGACACATTTGAGACACGAGCACTTGTCGTTAAACGCTAT
GTCATACTTTATTTTATAGACGAAAGTAGAAAAGAGATTGTAGTCTCCCACATCTTTAGTTCTAAAAGCGACTATATCAA
GTTGTTATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10995.70 Da
• Isoelectric Point: 4.5576

>AT25490 WP_002889575.1 NC_015760:45089-45376 [Streptococcus salivarius CCHSS3]
MTVVEKRVQVNFQTNPILLERARKIVKANNLDMSKSFNLFLETIVATEQIPVMTEDELLKERLFRQLKAEVAESVAEYQA
GNIIPLEEVKDEYNL

Nucleotide

• Length: 288 bp

>AT25490 NC_015760:45089-45376 [Streptococcus salivarius CCHSS3]
ATGACTGTTGTAGAGAAGCGTGTTCAAGTAAATTTCCAAACTAACCCGATTTTGTTGGAAAGGGCAAGAAAAATTGTAAA
GGCAAATAATTTAGATATGAGTAAATCGTTTAATTTGTTTTTGGAGACGATTGTTGCTACCGAGCAAATACCAGTAATGA
CGGAGGATGAATTGCTAAAAGAAAGACTGTTTAGGCAGCTTAAAGCTGAAGTAGCAGAGAGTGTAGCTGAGTATCAGGCG
GGTAATATAATACCCCTTGAGGAGGTTAAGGATGAATACAACCTATAG

Structures

Toxin

• AlphaFold DB: F8LGD0

Antitoxin

• AlphaFold DB: F8LGC9