25487

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3755357..3755886 Replicon chromosome
Accession NC_015758
Organism Mycobacterium africanum GM041182

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag MAF_RS17560 Protein ID WP_003417760.1
Coordinates 3755629..3755886 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag MAF_RS17555 Protein ID WP_003417757.1
Coordinates 3755357..3755632 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAF_RS22500 3752155..3753592 - 1438 Protein_3434 FAD-binding oxidoreductase -
MAF_RS17540 3753695..3754084 + 390 WP_003417745.1 DUF732 domain-containing protein -
MAF_RS17545 3754098..3754391 - 294 WP_003417749.1 DUF3017 domain-containing protein -
MAF_RS17550 3754388..3755233 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
MAF_RS17555 3755357..3755632 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
MAF_RS17560 3755629..3755886 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
MAF_RS17565 3755928..3757118 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
MAF_RS17570 3757235..3757603 + 369 WP_003417765.1 FHA domain-containing protein -
MAF_RS17575 3757600..3758151 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
MAF_RS17580 3758158..3758739 - 582 WP_003417769.1 ATP/GTP-binding protein -
MAF_RS17585 3758720..3759088 - 369 WP_003417772.1 DUF742 domain-containing protein -
MAF_RS17590 3759066..3759458 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T25487 WP_003417760.1 NC_015758:3755629-3755886 [Mycobacterium tuberculosis variant africanum GM041182]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T25487 NC_015758:3755629-3755886 [Mycobacterium tuberculosis variant africanum GM041182]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT25487 WP_003417757.1 NC_015758:3755357-3755632 [Mycobacterium tuberculosis variant africanum GM041182]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT25487 NC_015758:3755357-3755632 [Mycobacterium tuberculosis variant africanum GM041182]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
AlphaFold DB G0TI94

References