Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3710335..3710960 Replicon chromosome
Accession NZ_CP103295
Organism Escherichia coli strain 2e

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NW892_RS17780 Protein ID WP_000911330.1
Coordinates 3710335..3710733 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NW892_RS17785 Protein ID WP_000450524.1
Coordinates 3710733..3710960 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW892_RS17760 (3706213) 3706213..3706413 + 201 WP_000383836.1 YpfN family protein -
NW892_RS17765 (3706523) 3706523..3707221 - 699 WP_000679823.1 esterase -
NW892_RS17770 (3707295) 3707295..3709310 - 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
NW892_RS17775 (3709325) 3709325..3710188 - 864 WP_001267507.1 neutral zinc metallopeptidase -
NW892_RS17780 (3710335) 3710335..3710733 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
NW892_RS17785 (3710733) 3710733..3710960 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NW892_RS17790 (3711114) 3711114..3711827 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NW892_RS17795 (3712040) 3712040..3713074 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NW892_RS17800 (3713091) 3713091..3713969 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NW892_RS17805 (3714115) 3714115..3714687 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NW892_RS17810 (3714687) 3714687..3715157 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T254869 WP_000911330.1 NZ_CP103295:c3710733-3710335 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT254869 WP_000450524.1 NZ_CP103295:c3710960-3710733 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References