Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1527191..1527809 Replicon chromosome
Accession NZ_CP103295
Organism Escherichia coli strain 2e

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NW892_RS07200 Protein ID WP_001291435.1
Coordinates 1527191..1527409 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NW892_RS07205 Protein ID WP_000344800.1
Coordinates 1527435..1527809 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW892_RS07165 (1522480) 1522480..1523052 + 573 WP_000779831.1 YbaY family lipoprotein -
NW892_RS07170 (1523083) 1523083..1523394 - 312 WP_000409911.1 MGMT family protein -
NW892_RS07180 (1523773) 1523773..1524126 + 354 WP_000878140.1 DUF1428 domain-containing protein -
NW892_RS07185 (1524168) 1524168..1525718 - 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NW892_RS07190 (1525882) 1525882..1526352 - 471 WP_000136192.1 YlaC family protein -
NW892_RS07195 (1526468) 1526468..1527019 - 552 WP_000102568.1 maltose O-acetyltransferase -
NW892_RS07200 (1527191) 1527191..1527409 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NW892_RS07205 (1527435) 1527435..1527809 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NW892_RS07210 (1528355) 1528355..1531504 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NW892_RS07215 (1531527) 1531527..1532720 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T254862 WP_001291435.1 NZ_CP103295:c1527409-1527191 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT254862 WP_000344800.1 NZ_CP103295:c1527809-1527435 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References