Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 795800..796297 Replicon chromosome
Accession NZ_CP103295
Organism Escherichia coli strain 2e

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NW892_RS03675 Protein ID WP_001173343.1
Coordinates 796124..796297 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag NW892_RS03670 Protein ID WP_001425728.1
Coordinates 795800..796096 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW892_RS03650 (792531) 792531..793250 - 720 WP_000611288.1 two-component system response regulator DcuR -
NW892_RS03655 (793247) 793247..794878 - 1632 WP_001216487.1 sensor histidine kinase -
NW892_RS03660 (795059) 795059..795289 + 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
NW892_RS03665 (795301) 795301..795573 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
NW892_RS03670 (795800) 795800..796096 + 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NW892_RS03675 (796124) 796124..796297 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NW892_RS03680 (796416) 796416..797933 - 1518 WP_001295074.1 lysine--tRNA ligase -
NW892_RS03685 (798170) 798170..799627 - 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T254861 WP_001173343.1 NZ_CP103295:796124-796297 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT254861 WP_001425728.1 NZ_CP103295:795800-796096 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References