Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 12659..13245 Replicon chromosome
Accession NZ_CP103295
Organism Escherichia coli strain 2e

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag NW892_RS00075 Protein ID WP_042014162.1
Coordinates 13015..13245 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag NW892_RS00070 Protein ID WP_000593555.1
Coordinates 12659..13018 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW892_RS00045 (8791) 8791..9735 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
NW892_RS00050 (9732) 9732..10565 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
NW892_RS00055 (10565) 10565..11329 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
NW892_RS00060 (11326) 11326..12132 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
NW892_RS00065 (12138) 12138..12539 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
NW892_RS00070 (12659) 12659..13018 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NW892_RS00075 (13015) 13015..13245 - 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
NW892_RS00080 (13349) 13349..14473 - 1125 WP_001314210.1 ABC transporter permease -
NW892_RS00085 (14473) 14473..17208 - 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T254860 WP_042014162.1 NZ_CP103295:c13245-13015 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT254860 WP_000593555.1 NZ_CP103295:c13018-12659 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References