Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3733434..3734070 Replicon chromosome
Accession NZ_CP103290
Organism Bacillus atrophaeus strain NS2

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag NXY85_RS18950 Protein ID WP_003156187.1
Coordinates 3733720..3734070 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A837XXL9
Locus tag NXY85_RS18945 Protein ID WP_003328141.1
Coordinates 3733434..3733715 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXY85_RS18925 3729730..3730329 - 600 WP_258728654.1 rhomboid family intramembrane serine protease -
NXY85_RS18930 3730429..3730794 + 366 WP_061669621.1 holo-ACP synthase -
NXY85_RS18935 3730962..3731978 + 1017 WP_106034464.1 outer membrane lipoprotein carrier protein LolA -
NXY85_RS18940 3732146..3733315 + 1170 WP_010789628.1 alanine racemase -
NXY85_RS18945 3733434..3733715 + 282 WP_003328141.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
NXY85_RS18950 3733720..3734070 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
NXY85_RS18955 3734186..3735004 + 819 WP_061572303.1 RsbT co-antagonist protein RsbRA -
NXY85_RS18960 3735009..3735374 + 366 WP_010789626.1 RsbT antagonist protein RsbS -
NXY85_RS18965 3735377..3735778 + 402 WP_003328144.1 serine/threonine-protein kinase RsbT -
NXY85_RS18970 3735790..3736797 + 1008 WP_151291230.1 PP2C family protein-serine/threonine phosphatase -
NXY85_RS18975 3736857..3737186 + 330 WP_003328146.1 anti-sigma factor antagonist RsbV -
NXY85_RS18980 3737183..3737665 + 483 WP_003328147.1 anti-sigma B factor RsbW -
NXY85_RS18985 3737631..3738419 + 789 WP_003328149.1 RNA polymerase sigma factor SigB -
NXY85_RS18990 3738419..3739018 + 600 WP_003328150.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T254857 WP_003156187.1 NZ_CP103290:3733720-3734070 [Bacillus atrophaeus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10451.83 Da        Isoelectric Point: 5.1903

>AT254857 WP_003328141.1 NZ_CP103290:3733434-3733715 [Bacillus atrophaeus]
MSESSATTEMMISLPEALVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8

Antitoxin

Source ID Structure
AlphaFold DB A0A837XXL9

References