Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 341640..342556 Replicon chromosome
Accession NZ_CP103290
Organism Bacillus atrophaeus strain NS2

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag NXY85_RS01860 Protein ID WP_258729068.1
Coordinates 341810..342556 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A837Y0B4
Locus tag NXY85_RS01855 Protein ID WP_010788357.1
Coordinates 341640..341810 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXY85_RS01820 338396..338725 + 330 WP_258729065.1 XkdW family protein -
NXY85_RS01825 338722..338886 + 165 WP_061571316.1 XkdX family protein -
NXY85_RS01830 338962..339810 + 849 WP_258729066.1 phage portal protein -
NXY85_RS01835 339884..340162 + 279 WP_003327427.1 hemolysin XhlA family protein -
NXY85_RS01840 340175..340438 + 264 WP_003327426.1 phage holin -
NXY85_RS01845 340451..341344 + 894 WP_003327425.1 N-acetylmuramoyl-L-alanine amidase -
NXY85_RS01850 341420..341542 - 123 WP_010788356.1 hypothetical protein -
NXY85_RS01855 341640..341810 - 171 WP_010788357.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
NXY85_RS01860 341810..342556 - 747 WP_258729068.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
NXY85_RS01865 342665..343663 - 999 WP_003327422.1 inorganic phosphate transporter -
NXY85_RS01870 343676..344293 - 618 WP_003327421.1 DUF47 domain-containing protein -
NXY85_RS01875 344581..345897 - 1317 WP_258729069.1 amino acid permease -
NXY85_RS01880 346317..347267 + 951 WP_258729070.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 306685..363374 56689


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29096.63 Da        Isoelectric Point: 4.5650

>T254856 WP_258729068.1 NZ_CP103290:c342556-341810 [Bacillus atrophaeus]
MLLFFQIMVWCIMAALGLYVYAVWRFEAKVKEKMFAIRKTWYLIFVIGAMVYWTYDPSSLFREWTNYLIVAVSFALVDAF
IFLSAYVKKLAGNELETDTREILEENNEMLHVYLDKLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CEYSTQLEKDRLTEHMDDAFEVQSRLDRKDVYYDQHGKLALIPFTVQTRSYVIKLASDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6605.59 Da        Isoelectric Point: 11.0258

>AT254856 WP_010788357.1 NZ_CP103290:c341810-341640 [Bacillus atrophaeus]
MERAFQNDHSPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837Y0B4

References