Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3478644..3479257 Replicon chromosome
Accession NZ_CP103242
Organism Parabacteroides distasonis strain BFG-275

Toxin (Protein)


Gene name hicA Uniprot ID A0A069SEK0
Locus tag NXY26_RS15415 Protein ID WP_036615281.1
Coordinates 3478644..3478904 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID E1YXL0
Locus tag NXY26_RS15420 Protein ID WP_005866743.1
Coordinates 3478916..3479257 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXY26_RS15400 (NXY26_15400) 3474335..3475741 - 1407 WP_005866749.1 di-heme oxidoredictase family protein -
NXY26_RS15405 (NXY26_15405) 3475759..3476970 - 1212 WP_008778472.1 imelysin family protein -
NXY26_RS15410 (NXY26_15410) 3477001..3478314 - 1314 WP_258919249.1 porin -
NXY26_RS15415 (NXY26_15415) 3478644..3478904 + 261 WP_036615281.1 type II toxin-antitoxin system HicA family toxin Toxin
NXY26_RS15420 (NXY26_15420) 3478916..3479257 + 342 WP_005866743.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NXY26_RS15425 (NXY26_15425) 3479591..3480496 - 906 WP_121962007.1 transcriptional regulator -
NXY26_RS15430 (NXY26_15430) 3480634..3481617 - 984 WP_016270043.1 transposase -
NXY26_RS15435 (NXY26_15435) 3481583..3482200 - 618 WP_258919250.1 hypothetical protein -
NXY26_RS15440 (NXY26_15440) 3483146..3483301 - 156 Protein_3022 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-79)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10017.55 Da        Isoelectric Point: 9.8565

>T254852 WP_036615281.1 NZ_CP103242:3478644-3478904 [Parabacteroides distasonis]
MGSKEKLIEHFCKLPKDFTYEETLKLLSSYGYNEHNKGATSGSRVRFKNEQTGQYIDIHKPHPGSIMKEWMMKAIYQHLK
SNGLIK

Download         Length: 261 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12391.06 Da        Isoelectric Point: 4.8780

>AT254852 WP_005866743.1 NZ_CP103242:3478916-3479257 [Parabacteroides distasonis]
MDYLEYKGYKGSVEYSKADNCLCGKVLGMSKDLILYEGNTIDELRADFEAGVESYLAGCLADGVEPRKPYSGTLNIRISP
EIHSRIAALAQEAGTTINGYIKQALENQLKLAH

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069SEK0

Antitoxin

Source ID Structure
AlphaFold DB A0A069SEG1

References