Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3361220..3361833 Replicon chromosome
Accession NZ_CP103178
Organism Parabacteroides distasonis strain BFG-158

Toxin (Protein)


Gene name hicA Uniprot ID A0A069SEK0
Locus tag NXY22_RS14550 Protein ID WP_036615281.1
Coordinates 3361220..3361480 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID E1YXL0
Locus tag NXY22_RS14555 Protein ID WP_005866743.1
Coordinates 3361492..3361833 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXY22_RS14535 (NXY22_14535) 3356911..3358317 - 1407 WP_005861168.1 di-heme oxidoredictase family protein -
NXY22_RS14540 (NXY22_14540) 3358335..3359546 - 1212 WP_036652038.1 imelysin family protein -
NXY22_RS14545 (NXY22_14545) 3359577..3360890 - 1314 WP_005861166.1 porin -
NXY22_RS14550 (NXY22_14550) 3361220..3361480 + 261 WP_036615281.1 type II toxin-antitoxin system HicA family toxin Toxin
NXY22_RS14555 (NXY22_14555) 3361492..3361833 + 342 WP_005866743.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NXY22_RS14560 (NXY22_14560) 3362165..3363070 - 906 WP_009276446.1 transcriptional regulator -
NXY22_RS14565 (NXY22_14565) 3364327..3364482 - 156 Protein_2848 AAA family ATPase -
NXY22_RS14570 (NXY22_14570) 3364859..3366406 + 1548 WP_036615283.1 arylsulfatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-79)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10017.55 Da        Isoelectric Point: 9.8565

>T254851 WP_036615281.1 NZ_CP103178:3361220-3361480 [Parabacteroides distasonis]
MGSKEKLIEHFCKLPKDFTYEETLKLLSSYGYNEHNKGATSGSRVRFKNEQTGQYIDIHKPHPGSIMKEWMMKAIYQHLK
SNGLIK

Download         Length: 261 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12391.06 Da        Isoelectric Point: 4.8780

>AT254851 WP_005866743.1 NZ_CP103178:3361492-3361833 [Parabacteroides distasonis]
MDYLEYKGYKGSVEYSKADNCLCGKVLGMSKDLILYEGNTIDELRADFEAGVESYLAGCLADGVEPRKPYSGTLNIRISP
EIHSRIAALAQEAGTTINGYIKQALENQLKLAH

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069SEK0

Antitoxin

Source ID Structure
AlphaFold DB A0A069SEG1

References