Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 859255..859864 Replicon chromosome
Accession NZ_CP103108
Organism Parabacteroides faecis strain BFG-489

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NXY11_RS03630 Protein ID WP_258916301.1
Coordinates 859255..859515 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NXY11_RS03635 Protein ID WP_258916302.1
Coordinates 859523..859864 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXY11_RS03615 (NXY11_03615) 855189..858272 + 3084 WP_258916298.1 BACON domain-containing carbohydrate-binding protein -
NXY11_RS03620 (NXY11_03620) 858316..858591 + 276 WP_258916299.1 HU family DNA-binding protein -
NXY11_RS03625 (NXY11_03625) 858705..859220 + 516 WP_258916300.1 hypothetical protein -
NXY11_RS03630 (NXY11_03630) 859255..859515 + 261 WP_258916301.1 type II toxin-antitoxin system HicA family toxin Toxin
NXY11_RS03635 (NXY11_03635) 859523..859864 + 342 WP_258916302.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NXY11_RS03640 (NXY11_03640) 860001..860993 - 993 WP_258916303.1 helix-turn-helix transcriptional regulator -
NXY11_RS03645 (NXY11_03645) 861122..861532 + 411 WP_258916304.1 hypothetical protein -
NXY11_RS03650 (NXY11_03650) 861813..862118 + 306 WP_258916305.1 hypothetical protein -
NXY11_RS03655 (NXY11_03655) 862076..862624 - 549 WP_258916306.1 DNA-3-methyladenine glycosylase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-79)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9996.58 Da        Isoelectric Point: 10.2532

>T254850 WP_258916301.1 NZ_CP103108:859255-859515 [Parabacteroides faecis]
MGTKDKLIDRFCKLPKDFTYDETVKLLSGFGYNVHNKGVTSGSRIRFKNDQTGQYIDIHKPHPGSIMKEWMMKSIYQHLK
SNGFIK

Download         Length: 261 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12426.14 Da        Isoelectric Point: 4.7009

>AT254850 WP_258916302.1 NZ_CP103108:859523-859864 [Parabacteroides faecis]
MDCLEYKGYKGSVEYSKADNCLFGKVLGMSKDLILYEGSTIDELRADFEAGIDSYIAGCEADGVEPRKPYSGTLNIRISP
EVHSRIAMLAQEAGITINGYIKNALENQLKMAH

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References