254829

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1348118..1349034 Replicon chromosome
Accession NZ_CP103066
Organism Bacillus subtilis strain 0137

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag NXS96_RS07100 Protein ID WP_003244695.1
Coordinates 1348288..1349034 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag NXS96_RS07095 Protein ID WP_003232646.1
Coordinates 1348118..1348288 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXS96_RS07060 (1344981) 1344981..1345310 + 330 WP_003232660.1 XkdW family protein -
NXS96_RS07065 (1345307) 1345307..1345471 + 165 WP_003232658.1 XkdX family protein -
NXS96_RS07070 (1345515) 1345515..1346354 + 840 WP_003245597.1 phage-like element PBSX protein XepA -
NXS96_RS07075 (1346407) 1346407..1346676 + 270 WP_258735280.1 hemolysin XhlA family protein -
NXS96_RS07080 (1346689) 1346689..1346952 + 264 WP_003232653.1 phage holin -
NXS96_RS07085 (1346965) 1346965..1347858 + 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
NXS96_RS07090 (1347895) 1347895..1348032 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
NXS96_RS07095 (1348118) 1348118..1348288 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
NXS96_RS07100 (1348288) 1348288..1349034 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
NXS96_RS07105 (1349144) 1349144..1350145 - 1002 WP_003232642.1 inorganic phosphate transporter -
NXS96_RS07110 (1350158) 1350158..1350775 - 618 WP_003218470.1 DUF47 domain-containing protein -
NXS96_RS07115 (1351051) 1351051..1352367 - 1317 WP_003244819.1 serine/threonine exchanger -
NXS96_RS07120 (1352756) 1352756..1353706 + 951 WP_003245086.1 ring-cleaving dioxygenase -
NXS96_RS07125 (1353807) 1353807..1353953 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T254829 WP_003244695.1 NZ_CP103066:c1349034-1348288 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT254829 WP_003232646.1 NZ_CP103066:c1348288-1348118 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References