Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 518331..518967 | Replicon | chromosome |
Accession | NZ_CP103066 | ||
Organism | Bacillus subtilis strain 0137 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | G4NU33 |
Locus tag | NXS96_RS02640 | Protein ID | WP_003156187.1 |
Coordinates | 518617..518967 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | G4NU32 |
Locus tag | NXS96_RS02635 | Protein ID | WP_003225183.1 |
Coordinates | 518331..518612 (+) | Length | 94 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NXS96_RS02615 (514690) | 514690..515289 | - | 600 | WP_003246687.1 | rhomboid family intramembrane serine protease | - |
NXS96_RS02620 (515384) | 515384..515749 | + | 366 | WP_003234281.1 | holo-ACP synthase | - |
NXS96_RS02625 (515915) | 515915..516931 | + | 1017 | WP_003234282.1 | outer membrane lipoprotein carrier protein LolA | - |
NXS96_RS02630 (517046) | 517046..518215 | + | 1170 | WP_003234284.1 | alanine racemase | - |
NXS96_RS02635 (518331) | 518331..518612 | + | 282 | WP_003225183.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
NXS96_RS02640 (518617) | 518617..518967 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
NXS96_RS02645 (519082) | 519082..519906 | + | 825 | WP_009966610.1 | RsbT co-antagonist protein RsbRA | - |
NXS96_RS02650 (519911) | 519911..520276 | + | 366 | WP_003225190.1 | RsbT antagonist protein RsbS | - |
NXS96_RS02655 (520280) | 520280..520681 | + | 402 | WP_003246640.1 | serine/threonine-protein kinase RsbT | - |
NXS96_RS02660 (520693) | 520693..521700 | + | 1008 | WP_003234295.1 | phosphoserine phosphatase RsbU | - |
NXS96_RS02665 (521762) | 521762..522091 | + | 330 | WP_003234298.1 | anti-sigma factor antagonist RsbV | - |
NXS96_RS02670 (522088) | 522088..522570 | + | 483 | WP_003234299.1 | anti-sigma B factor RsbW | - |
NXS96_RS02675 (522536) | 522536..523324 | + | 789 | WP_003246715.1 | RNA polymerase sigma factor SigB | - |
NXS96_RS02680 (523324) | 523324..523923 | + | 600 | WP_003246608.1 | phosphoserine phosphatase RsbX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T254828 WP_003156187.1 NZ_CP103066:518617-518967 [Bacillus subtilis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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