Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 43794..44446 Replicon plasmid p2
Accession NZ_CP102995
Organism Klebsiella pneumoniae strain KPA3

Toxin (Protein)


Gene name vagD Uniprot ID A0A8A2Q2K1
Locus tag NW255_RS26900 Protein ID WP_017901321.1
Coordinates 44021..44446 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A853H7M9
Locus tag NW255_RS26895 Protein ID WP_001261275.1
Coordinates 43794..44024 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW255_RS26890 (NW255_26890) 40965..43541 + 2577 WP_017901322.1 nuclease domain-containing protein -
NW255_RS26895 (NW255_26895) 43794..44024 + 231 WP_001261275.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NW255_RS26900 (NW255_26900) 44021..44446 + 426 WP_017901321.1 type II toxin-antitoxin system VapC family toxin Toxin
NW255_RS26905 (NW255_26905) 44464..45432 + 969 WP_077254762.1 IS5 family transposase -
NW255_RS26910 (NW255_26910) 45491..46027 + 537 Protein_50 integrase core domain-containing protein -
NW255_RS26915 (NW255_26915) 46080..46253 + 174 Protein_51 nuclease -
NW255_RS26920 (NW255_26920) 46440..47996 + 1557 WP_025999314.1 sensor domain-containing diguanylate cyclase -
NW255_RS26925 (NW255_26925) 48088..48315 - 228 Protein_53 IS3 family transposase -
NW255_RS26930 (NW255_26930) 48326..48496 + 171 Protein_54 LysR family transcriptional regulator -
NW255_RS26935 (NW255_26935) 48621..48737 - 117 Protein_55 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid catA1 / tet(D) - 1..121101 121101
- flank IS/Tn - - 44464..45432 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15412.91 Da        Isoelectric Point: 7.1364

>T254824 WP_017901321.1 NZ_CP102995:44021-44446 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVGFVE

Download         Length: 426 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8707.72 Da        Isoelectric Point: 4.3410

>AT254824 WP_001261275.1 NZ_CP102995:43794-44024 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8A2Q2K1

Antitoxin

Source ID Structure
AlphaFold DB A0A853H7M9

References