Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 43794..44446 Replicon plasmid p2
Accession NZ_CP102995
Organism Klebsiella pneumoniae strain KPA3

Toxin (Protein)


Gene name vagD Uniprot ID A0A8A2Q2K1
Locus tag NW255_RS26900 Protein ID WP_017901321.1
Coordinates 44021..44446 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A853H7M9
Locus tag NW255_RS26895 Protein ID WP_001261275.1
Coordinates 43794..44024 (+) Length 77 a.a.

Genomic Context


NW255_RS26890NW255_RS26895NW255_RS26900NW255_RS26905NW255_RS26910NW255_RS26915NW255_RS26920NW255_RS26930NW255_RS26925NW255_RS26935
Location: 40965..43541 (2577 bp)
Type: Others
Protein ID: WP_017901322.1
Location: 43794..44024 (231 bp)
Type: Antitoxin
Protein ID: WP_001261275.1
Location: 44021..44446 (426 bp)
Type: Toxin
Protein ID: WP_017901321.1
Location: 44464..45432 (969 bp)
Type: Others
Protein ID: WP_077254762.1
Location: 45491..46027 (537 bp)
Type: Others
Protein ID: Protein_50
Location: 46080..46253 (174 bp)
Type: Others
Protein ID: Protein_51
Location: 46440..47996 (1557 bp)
Type: Others
Protein ID: WP_025999314.1
Location: 48326..48496 (171 bp)
Type: Others
Protein ID: Protein_54
Location: 48088..48315 (228 bp)
Type: Others
Protein ID: Protein_53
Location: 48621..48737 (117 bp)
Type: Others
Protein ID: Protein_55
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NW255_RS26890 (NW255_26890)40965..43541+2577WP_017901322.1nuclease domain-containing protein-
NW255_RS26895 (NW255_26895)43794..44024+231WP_001261275.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
NW255_RS26900 (NW255_26900)44021..44446+426WP_017901321.1type II toxin-antitoxin system VapC family toxinToxin
NW255_RS26905 (NW255_26905)44464..45432+969WP_077254762.1IS5 family transposase-
NW255_RS26910 (NW255_26910)45491..46027+537Protein_50integrase core domain-containing protein-
NW255_RS26915 (NW255_26915)46080..46253+174Protein_51nuclease-
NW255_RS26920 (NW255_26920)46440..47996+1557WP_025999314.1sensor domain-containing diguanylate cyclase-
NW255_RS26925 (NW255_26925)48088..48315-228Protein_53IS3 family transposase-
NW255_RS26930 (NW255_26930)48326..48496+171Protein_54LysR family transcriptional regulator-
NW255_RS26935 (NW255_26935)48621..48737-117Protein_55transposase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidcatA1 / tet(D)-1..121101121101
-flankIS/Tn--44464..45432968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-129)

Antitoxin

(7-47)


Sequences


Toxin        


Download         Length: 142 a.a.        Molecular weight: 15412.91 Da        Isoelectric Point: 7.1364

>T254824 WP_017901321.1 NZ_CP102995:44021-44446 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVGFVE

Download         Length: 426 bp


Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8707.72 Da        Isoelectric Point: 4.3410

>AT254824 WP_001261275.1 NZ_CP102995:43794-44024 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDP

Download         Length: 231 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A8A2Q2K1


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A853H7M9

References