Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4881548..4883229 Replicon chromosome
Accession NZ_CP102993
Organism Klebsiella pneumoniae strain KPA3

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag NW255_RS23905 Protein ID WP_004178299.1
Coordinates 4881548..4882465 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag NW255_RS23910 Protein ID WP_004177809.1
Coordinates 4882471..4883229 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW255_RS23885 (4876854) 4876854..4878374 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NW255_RS23890 (4878371) 4878371..4879369 + 999 WP_002885172.1 ribose ABC transporter permease -
NW255_RS23895 (4879400) 4879400..4880341 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NW255_RS23900 (4880416) 4880416..4881423 + 1008 WP_004178300.1 carbohydrate kinase family protein -
NW255_RS23905 (4881548) 4881548..4882465 - 918 WP_004178299.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NW255_RS23910 (4882471) 4882471..4883229 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NW255_RS23915 (4883315) 4883315..4884043 - 729 WP_004178298.1 response regulator transcription factor -
NW255_RS23920 (4884316) 4884316..4886463 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
NW255_RS23925 (4886460) 4886460..4886603 - 144 WP_022631365.1 hypothetical protein -
NW255_RS23930 (4887041) 4887041..4887727 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34649.06 Da        Isoelectric Point: 5.4707

>T254822 WP_004178299.1 NZ_CP102993:c4882465-4881548 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT254822 WP_004177809.1 NZ_CP102993:c4883229-4882471 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References