Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4725852..4726368 Replicon chromosome
Accession NZ_CP102993
Organism Klebsiella pneumoniae strain KPA3

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag NW255_RS23115 Protein ID WP_004178374.1
Coordinates 4725852..4726136 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NW255_RS23120 Protein ID WP_002886901.1
Coordinates 4726126..4726368 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW255_RS23090 (4721336) 4721336..4721599 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
NW255_RS23095 (4721729) 4721729..4721902 + 174 WP_032408826.1 hypothetical protein -
NW255_RS23100 (4721905) 4721905..4722648 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NW255_RS23105 (4723005) 4723005..4725143 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NW255_RS23110 (4725384) 4725384..4725848 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NW255_RS23115 (4725852) 4725852..4726136 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NW255_RS23120 (4726126) 4726126..4726368 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NW255_RS23125 (4726446) 4726446..4728356 - 1911 WP_004178373.1 PRD domain-containing protein -
NW255_RS23130 (4728379) 4728379..4729533 - 1155 WP_004178372.1 lactonase family protein -
NW255_RS23135 (4729600) 4729600..4730340 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T254821 WP_004178374.1 NZ_CP102993:c4726136-4725852 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT254821 WP_002886901.1 NZ_CP102993:c4726368-4726126 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References