Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2687541..2689129 Replicon chromosome
Accession NZ_CP102993
Organism Klebsiella pneumoniae strain KPA3

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NW255_RS13310 Protein ID WP_004179815.1
Coordinates 2687541..2688863 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NW255_RS13315 Protein ID WP_004176198.1
Coordinates 2688863..2689129 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW255_RS13295 (2682597) 2682597..2685098 + 2502 WP_020323802.1 fimbria/pilus outer membrane usher protein -
NW255_RS13300 (2685086) 2685086..2686090 + 1005 WP_004179822.1 fimbrial protein -
NW255_RS13305 (2686232) 2686232..2687524 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NW255_RS13310 (2687541) 2687541..2688863 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
NW255_RS13315 (2688863) 2688863..2689129 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NW255_RS13320 (2689395) 2689395..2689721 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NW255_RS13325 (2689718) 2689718..2690218 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NW255_RS13330 (2690196) 2690196..2691575 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
NW255_RS13335 (2691921) 2691921..2693075 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NW255_RS13340 (2693056) 2693056..2693979 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T254817 WP_004179815.1 NZ_CP102993:c2688863-2687541 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT254817 WP_004176198.1 NZ_CP102993:c2689129-2688863 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References