Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 807544..808201 Replicon chromosome
Accession NZ_CP102993
Organism Klebsiella pneumoniae strain KPA3

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NW255_RS03980 Protein ID WP_002916310.1
Coordinates 807791..808201 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NW255_RS03975 Protein ID WP_002916312.1
Coordinates 807544..807810 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW255_RS03950 (802700) 802700..804133 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
NW255_RS03955 (804252) 804252..804980 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NW255_RS03960 (805030) 805030..805341 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NW255_RS03965 (805505) 805505..806164 + 660 WP_002916317.1 hemolysin III family protein -
NW255_RS03970 (806315) 806315..807298 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
NW255_RS03975 (807544) 807544..807810 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NW255_RS03980 (807791) 807791..808201 + 411 WP_002916310.1 protein YgfX Toxin
NW255_RS03985 (808208) 808208..808729 - 522 WP_004144730.1 flavodoxin FldB -
NW255_RS03990 (808830) 808830..809726 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NW255_RS03995 (809749) 809749..810462 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NW255_RS04000 (810468) 810468..812201 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T254812 WP_002916310.1 NZ_CP102993:807791-808201 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT254812 WP_002916312.1 NZ_CP102993:807544-807810 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References