Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 660907..661586 Replicon chromosome
Accession NZ_CP102993
Organism Klebsiella pneumoniae strain KPA3

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag NW255_RS03235 Protein ID WP_020324801.1
Coordinates 661245..661586 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag NW255_RS03230 Protein ID WP_020324792.1
Coordinates 660907..661224 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW255_RS03205 (656121) 656121..659273 + 3153 WP_022631414.1 AIDA repeat-containing protein -
NW255_RS03210 (659366) 659366..659605 + 240 WP_020324820.1 DUF905 domain-containing protein -
NW255_RS03215 (659708) 659708..660166 + 459 WP_020324813.1 antirestriction protein -
NW255_RS03220 (660182) 660182..660658 + 477 WP_020324797.1 RadC family protein -
NW255_RS03225 (660667) 660667..660894 + 228 WP_020324796.1 DUF987 domain-containing protein -
NW255_RS03230 (660907) 660907..661224 + 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NW255_RS03235 (661245) 661245..661586 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
NW255_RS03240 (661702) 661702..662535 + 834 WP_020324805.1 DUF4942 domain-containing protein -
NW255_RS03250 (662838) 662838..663344 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
NW255_RS03255 (663444) 663444..665285 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 641832..662535 20703


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T254811 WP_020324801.1 NZ_CP102993:661245-661586 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT254811 WP_020324792.1 NZ_CP102993:660907-661224 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References