Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 95468..96111 Replicon plasmid p1
Accession NZ_CP102988
Organism Klebsiella pneumoniae strain KPA2

Toxin (Protein)


Gene name vagD Uniprot ID A0A155IU92
Locus tag NW253_RS26360 Protein ID WP_000754567.1
Coordinates 95695..96111 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A853H7M9
Locus tag NW253_RS26355 Protein ID WP_001261275.1
Coordinates 95468..95698 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW253_RS26350 (NW253_26350) 92639..95215 + 2577 WP_017901322.1 nuclease domain-containing protein -
NW253_RS26355 (NW253_26355) 95468..95698 + 231 WP_001261275.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NW253_RS26360 (NW253_26360) 95695..96111 + 417 WP_000754567.1 type II toxin-antitoxin system VapC family toxin Toxin
NW253_RS26365 (NW253_26365) 96419..97387 + 969 WP_016151349.1 IS5 family transposase -
NW253_RS26370 (NW253_26370) 97558..97977 - 420 WP_011251286.1 helix-turn-helix domain-containing protein -
NW253_RS26375 (NW253_26375) 97974..98285 - 312 WP_011251285.1 type II toxin-antitoxin system HigB family toxin -
NW253_RS26380 (NW253_26380) 98490..98927 - 438 Protein_103 DDE-type integrase/transposase/recombinase -
NW253_RS26385 (NW253_26385) 99041..99379 + 339 WP_023288266.1 transposase -
NW253_RS26390 (NW253_26390) 99376..99723 + 348 WP_032430752.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrB4 / blaDHA-1 / aph(3')-Ia / mph(A) - 1..188688 188688
- inside IScluster/Tn - - 96419..103049 6630


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15108.61 Da        Isoelectric Point: 8.5403

>T254807 WP_000754567.1 NZ_CP102988:95695-96111 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8707.72 Da        Isoelectric Point: 4.3410

>AT254807 WP_001261275.1 NZ_CP102988:95468-95698 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155IU92

Antitoxin

Source ID Structure
AlphaFold DB A0A853H7M9

References