Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 53680..54590 Replicon plasmid p1
Accession NZ_CP102988
Organism Klebsiella pneumoniae strain KPA2

Toxin (Protein)


Gene name - Uniprot ID R4YBC5
Locus tag NW253_RS26120 Protein ID WP_004144067.1
Coordinates 54120..54590 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6A8PHD0
Locus tag NW253_RS26115 Protein ID WP_023287184.1
Coordinates 53680..54123 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW253_RS26100 (NW253_26100) 48979..50160 + 1182 WP_023287181.1 hypothetical protein -
NW253_RS26105 (NW253_26105) 50157..52385 + 2229 WP_032430744.1 ThiF family adenylyltransferase -
NW253_RS26110 (NW253_26110) 52438..53579 + 1142 Protein_49 translesion error-prone DNA polymerase V subunit UmuC -
NW253_RS26115 (NW253_26115) 53680..54123 + 444 WP_023287184.1 DUF2384 domain-containing protein Antitoxin
NW253_RS26120 (NW253_26120) 54120..54590 + 471 WP_004144067.1 RES family NAD+ phosphorylase Toxin
NW253_RS26125 (NW253_26125) 54677..54997 + 321 Protein_52 IS5/IS1182 family transposase -
NW253_RS26130 (NW253_26130) 55030..55998 + 969 WP_074423483.1 IS5 family transposase -
NW253_RS26135 (NW253_26135) 56337..57092 - 756 Protein_54 M24 family metallopeptidase -
NW253_RS26145 (NW253_26145) 58529..58900 - 372 WP_258809046.1 aminopeptidase P family N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrB4 / blaDHA-1 / aph(3')-Ia / mph(A) - 1..188688 188688


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17573.83 Da        Isoelectric Point: 4.5152

>T254806 WP_004144067.1 NZ_CP102988:54120-54590 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16522.84 Da        Isoelectric Point: 10.3013

>AT254806 WP_023287184.1 NZ_CP102988:53680-54123 [Klebsiella pneumoniae]
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A384IED8

Antitoxin

Source ID Structure
AlphaFold DB A0A6A8PHD0

References