Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4879130..4880811 Replicon chromosome
Accession NZ_CP102987
Organism Klebsiella pneumoniae strain KPA2

Toxin (Protein)


Gene name mosT Uniprot ID A6TH06
Locus tag NW253_RS23915 Protein ID WP_015959269.1
Coordinates 4879130..4880005 (-) Length 292 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag NW253_RS23920 Protein ID WP_004177809.1
Coordinates 4880053..4880811 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW253_RS23895 (4874436) 4874436..4875956 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NW253_RS23900 (4875953) 4875953..4876951 + 999 WP_002885172.1 ribose ABC transporter permease -
NW253_RS23905 (4876982) 4876982..4877923 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NW253_RS23910 (4877998) 4877998..4879005 + 1008 WP_015959270.1 carbohydrate kinase family protein -
NW253_RS23915 (4879130) 4879130..4880005 - 876 WP_015959269.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NW253_RS23920 (4880053) 4880053..4880811 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NW253_RS23925 (4880897) 4880897..4881625 - 729 WP_032413197.1 response regulator transcription factor -
NW253_RS23930 (4881898) 4881898..4884045 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
NW253_RS23935 (4884042) 4884042..4884185 - 144 WP_162897205.1 hypothetical protein -
NW253_RS23940 (4884507) 4884507..4885193 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(7-264)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 292 a.a.        Molecular weight: 32990.17 Da        Isoelectric Point: 5.4637

>T254804 WP_015959269.1 NZ_CP102987:c4880005-4879130 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 876 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT254804 WP_004177809.1 NZ_CP102987:c4880811-4880053 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6TH06

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References