Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4719391..4719907 Replicon chromosome
Accession NZ_CP102987
Organism Klebsiella pneumoniae strain KPA2

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag NW253_RS23100 Protein ID WP_009486548.1
Coordinates 4719391..4719675 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NW253_RS23105 Protein ID WP_002886901.1
Coordinates 4719665..4719907 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW253_RS23075 (4714808) 4714808..4715071 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
NW253_RS23080 (4715201) 4715201..4715374 + 174 WP_032433782.1 hypothetical protein -
NW253_RS23085 (4715377) 4715377..4716120 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NW253_RS23090 (4716477) 4716477..4718615 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NW253_RS23095 (4718923) 4718923..4719387 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NW253_RS23100 (4719391) 4719391..4719675 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NW253_RS23105 (4719665) 4719665..4719907 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NW253_RS23110 (4719985) 4719985..4721895 - 1911 WP_009486549.1 PRD domain-containing protein -
NW253_RS23115 (4721918) 4721918..4723072 - 1155 WP_002886900.1 lactonase family protein -
NW253_RS23120 (4723139) 4723139..4723879 - 741 WP_258809005.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T254803 WP_009486548.1 NZ_CP102987:c4719675-4719391 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT254803 WP_002886901.1 NZ_CP102987:c4719907-4719665 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References