Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4609404..4610214 Replicon chromosome
Accession NZ_CP102987
Organism Klebsiella pneumoniae strain KPA2

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag NW253_RS22625 Protein ID WP_002887280.1
Coordinates 4609404..4609937 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NW253_RS22630 Protein ID WP_002887278.1
Coordinates 4609948..4610214 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW253_RS22620 (4608236) 4608236..4609357 + 1122 WP_009309849.1 cupin domain-containing protein -
NW253_RS22625 (4609404) 4609404..4609937 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
NW253_RS22630 (4609948) 4609948..4610214 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NW253_RS22635 (4610317) 4610317..4611750 - 1434 WP_023288193.1 Cu(+)/Ag(+) sensor histidine kinase -
NW253_RS22640 (4611740) 4611740..4612423 - 684 WP_032105399.1 copper response regulator transcription factor CusR -
NW253_RS22645 (4612596) 4612596..4613981 + 1386 WP_032431458.1 efflux transporter outer membrane subunit -
NW253_RS22650 (4613999) 4613999..4614304 + 306 WP_032432083.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T254802 WP_002887280.1 NZ_CP102987:c4609937-4609404 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT254802 WP_002887278.1 NZ_CP102987:c4610214-4609948 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References