Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2591006..2592594 Replicon chromosome
Accession NZ_CP102987
Organism Klebsiella pneumoniae strain KPA2

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag NW253_RS12695 Protein ID WP_002904792.1
Coordinates 2591006..2592328 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NW253_RS12700 Protein ID WP_002904790.1
Coordinates 2592328..2592594 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW253_RS12680 (2586062) 2586062..2588563 + 2502 WP_032433099.1 fimbria/pilus outer membrane usher protein -
NW253_RS12685 (2588551) 2588551..2589555 + 1005 WP_032433097.1 fimbrial protein -
NW253_RS12690 (2589697) 2589697..2590989 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NW253_RS12695 (2591006) 2591006..2592328 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
NW253_RS12700 (2592328) 2592328..2592594 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NW253_RS12705 (2592980) 2592980..2593306 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NW253_RS12710 (2593303) 2593303..2593803 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NW253_RS12715 (2593781) 2593781..2595160 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
NW253_RS12720 (2595506) 2595506..2596660 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NW253_RS12725 (2596641) 2596641..2597564 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T254800 WP_002904792.1 NZ_CP102987:c2592328-2591006 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT254800 WP_002904790.1 NZ_CP102987:c2592594-2592328 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References