Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1418427..1419070 Replicon chromosome
Accession NZ_CP102987
Organism Klebsiella pneumoniae strain KPA2

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NW253_RS06945 Protein ID WP_060588417.1
Coordinates 1418654..1419070 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A853H7M9
Locus tag NW253_RS06940 Protein ID WP_001261275.1
Coordinates 1418427..1418657 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW253_RS06925 (1413449) 1413449..1414536 + 1088 Protein_1350 transcriptional regulator -
NW253_RS06930 (1414539) 1414539..1416779 + 2241 WP_045326788.1 P-loop NTPase fold protein -
NW253_RS06935 (1417307) 1417307..1418122 - 816 WP_032433388.1 hypothetical protein -
NW253_RS06940 (1418427) 1418427..1418657 + 231 WP_001261275.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NW253_RS06945 (1418654) 1418654..1419070 + 417 WP_060588417.1 type II toxin-antitoxin system VapC family toxin Toxin
NW253_RS06950 (1419226) 1419226..1420206 + 981 WP_032433385.1 hypothetical protein -
NW253_RS06955 (1420401) 1420401..1421972 - 1572 WP_032433383.1 AAA family ATPase -
NW253_RS06960 (1422291) 1422291..1422539 + 249 WP_032433382.1 hypothetical protein -
NW253_RS06965 (1422598) 1422598..1423116 + 519 WP_045326794.1 hypothetical protein -
NW253_RS06970 (1423147) 1423147..1423638 + 492 WP_032433378.1 hypothetical protein -
NW253_RS06975 (1423698) 1423698..1423901 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1403063..1450145 47082


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15002.49 Da        Isoelectric Point: 7.8921

>T254794 WP_060588417.1 NZ_CP102987:1418654-1419070 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8707.72 Da        Isoelectric Point: 4.3410

>AT254794 WP_001261275.1 NZ_CP102987:1418427-1418657 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A853H7M9

References