Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 800273..800930 Replicon chromosome
Accession NZ_CP102987
Organism Klebsiella pneumoniae strain KPA2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NW253_RS03960 Protein ID WP_002916310.1
Coordinates 800520..800930 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NW253_RS03955 Protein ID WP_002916312.1
Coordinates 800273..800539 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW253_RS03930 (795429) 795429..796862 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
NW253_RS03935 (796981) 796981..797709 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NW253_RS03940 (797759) 797759..798070 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NW253_RS03945 (798234) 798234..798893 + 660 WP_002916317.1 hemolysin III family protein -
NW253_RS03950 (799044) 799044..800027 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NW253_RS03955 (800273) 800273..800539 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NW253_RS03960 (800520) 800520..800930 + 411 WP_002916310.1 protein YgfX Toxin
NW253_RS03965 (800937) 800937..801458 - 522 WP_004144730.1 flavodoxin FldB -
NW253_RS03970 (801559) 801559..802455 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NW253_RS03975 (802478) 802478..803191 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NW253_RS03980 (803197) 803197..804930 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T254793 WP_002916310.1 NZ_CP102987:800520-800930 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT254793 WP_002916312.1 NZ_CP102987:800273-800539 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References