Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2046650..2047179 Replicon chromosome
Accession NZ_CP102977
Organism Staphylococcus aureus strain 27-G-H

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW957_RS10090 Protein ID WP_000621175.1
Coordinates 2046650..2047012 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW957_RS10095 Protein ID WP_000948331.1
Coordinates 2047009..2047179 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW957_RS10070 (2043628) 2043628..2044398 - 771 WP_001041108.1 RNA polymerase sigma factor SigB -
NW957_RS10075 (2044373) 2044373..2044852 - 480 WP_001190829.1 anti-sigma B factor RsbW -
NW957_RS10080 (2044854) 2044854..2045180 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW957_RS10085 (2045299) 2045299..2046300 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW957_RS10090 (2046650) 2046650..2047012 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW957_RS10095 (2047009) 2047009..2047179 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW957_RS10100 (2047264) 2047264..2048412 - 1149 WP_072496962.1 alanine racemase -
NW957_RS10105 (2048478) 2048478..2048837 - 360 WP_061838820.1 holo-ACP synthase -
NW957_RS10110 (2048841) 2048841..2049332 - 492 WP_072496961.1 PH domain-containing protein -
NW957_RS10115 (2049319) 2049319..2050902 - 1584 WP_072496960.1 PH domain-containing protein -
NW957_RS10120 (2050895) 2050895..2051374 - 480 WP_001287079.1 hypothetical protein -
NW957_RS10125 (2051583) 2051583..2052143 - 561 WP_072496959.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254784 WP_000621175.1 NZ_CP102977:c2047012-2046650 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254784 WP_000948331.1 NZ_CP102977:c2047179-2047009 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References