Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1851913..1852689 Replicon chromosome
Accession NZ_CP102977
Organism Staphylococcus aureus strain 27-G-H

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW957_RS08880 Protein ID WP_000031108.1
Coordinates 1851913..1852065 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag NW957_RS08885 Protein ID WP_165468800.1
Coordinates 1852090..1852689 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW957_RS08865 (1847882) 1847882..1848703 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NW957_RS08870 (1849164) 1849164..1850549 - 1386 WP_000116231.1 class II fumarate hydratase -
NW957_RS08875 (1850745) 1850745..1851140 - 396 WP_000901023.1 hypothetical protein -
NW957_RS08880 (1851913) 1851913..1852065 - 153 WP_000031108.1 SAS053 family protein Toxin
NW957_RS08885 (1852090) 1852090..1852689 - 600 WP_165468800.1 glucosamine-6-phosphate isomerase Antitoxin
NW957_RS08890 (1852848) 1852848..1853318 - 471 WP_165468801.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW957_RS08895 (1853323) 1853323..1854450 - 1128 WP_000379986.1 tRNA epoxyqueuosine(34) reductase QueG -
NW957_RS08900 (1854601) 1854601..1855323 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW957_RS08905 (1855316) 1855316..1856773 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254779 WP_000031108.1 NZ_CP102977:c1852065-1851913 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22332.49 Da        Isoelectric Point: 5.1445

>AT254779 WP_165468800.1 NZ_CP102977:c1852689-1852090 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNTTTIAGFHLDTDLAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure

References