Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2099646..2100160 Replicon chromosome
Accession NZ_CP102975
Organism Staphylococcus aureus strain 16CS0209

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NW953_RS10230 Protein ID WP_000581792.1
Coordinates 2099646..2099855 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag NW953_RS10235 Protein ID WP_000138934.1
Coordinates 2099867..2100160 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW953_RS10210 (NW953_10210) 2095154..2096512 - 1359 WP_258409296.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW953_RS10215 (NW953_10215) 2096527..2097597 - 1071 WP_070004727.1 D-alanine--D-alanine ligase -
NW953_RS10220 (NW953_10220) 2097915..2099117 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NW953_RS10225 (NW953_10225) 2099381..2099518 - 138 WP_000828354.1 Lmo0850 family protein -
NW953_RS10230 (NW953_10230) 2099646..2099855 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NW953_RS10235 (NW953_10235) 2099867..2100160 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW953_RS10240 (NW953_10240) 2100326..2101810 + 1485 WP_258409297.1 cardiolipin synthase -
NW953_RS10245 (NW953_10245) 2101838..2102485 + 648 WP_258409298.1 HD domain-containing protein -
NW953_RS10250 (NW953_10250) 2103256..2104128 - 873 WP_000725802.1 membrane protein insertase YidC -
NW953_RS10255 (NW953_10255) 2104214..2104855 - 642 WP_258409299.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254771 WP_000581792.1 NZ_CP102975:c2099855-2099646 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT254771 WP_000138934.1 NZ_CP102975:c2100160-2099867 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References