25477

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2917507..2918221 Replicon chromosome
Accession NC_015758
Organism Mycobacterium africanum GM041182

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag MAF_RS13635 Protein ID WP_003413460.1
Coordinates 2917781..2918221 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag MAF_RS13630 Protein ID WP_003413456.1
Coordinates 2917507..2917794 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAF_RS13595 2912929..2913174 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
MAF_RS13600 2913171..2913575 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
MAF_RS13605 2913792..2914412 + 621 WP_003413441.1 DUF4178 domain-containing protein -
MAF_RS13610 2914423..2914917 + 495 WP_003413444.1 DUF2617 family protein -
MAF_RS13615 2914914..2915345 + 432 WP_003910600.1 DUF4247 domain-containing protein -
MAF_RS13620 2915370..2915828 + 459 WP_003413451.1 DUF350 domain-containing protein -
MAF_RS13625 2915825..2917396 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
MAF_RS13630 2917507..2917794 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
MAF_RS13635 2917781..2918221 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
MAF_RS13640 2918242..2918997 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
MAF_RS13645 2919130..2919726 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
MAF_RS13650 2919734..2920579 - 846 WP_003413466.1 acyl-CoA thioesterase II -
MAF_RS13655 2920608..2921507 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
MAF_RS13660 2921635..2922310 + 676 Protein_2673 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T25477 WP_003413460.1 NC_015758:2917781-2918221 [Mycobacterium tuberculosis variant africanum GM041182]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T25477 NC_015758:2917781-2918221 [Mycobacterium tuberculosis variant africanum GM041182]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT25477 WP_003413456.1 NC_015758:2917507-2917794 [Mycobacterium tuberculosis variant africanum GM041182]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT25477 NC_015758:2917507-2917794 [Mycobacterium tuberculosis variant africanum GM041182]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References