Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1923176..1923952 Replicon chromosome
Accession NZ_CP102975
Organism Staphylococcus aureus strain 16CS0209

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW953_RS09245 Protein ID WP_000031108.1
Coordinates 1923176..1923328 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag NW953_RS09250 Protein ID WP_001251219.1
Coordinates 1923353..1923952 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW953_RS09230 (NW953_09230) 1919151..1919972 + 822 WP_000669380.1 RluA family pseudouridine synthase -
NW953_RS09235 (NW953_09235) 1920423..1921808 - 1386 WP_000116238.1 class II fumarate hydratase -
NW953_RS09240 (NW953_09240) 1922004..1922399 - 396 WP_000901019.1 hypothetical protein -
NW953_RS09245 (NW953_09245) 1923176..1923328 - 153 WP_000031108.1 SAS053 family protein Toxin
NW953_RS09250 (NW953_09250) 1923353..1923952 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
NW953_RS09255 (NW953_09255) 1924111..1924581 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW953_RS09260 (NW953_09260) 1924586..1925713 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
NW953_RS09265 (NW953_09265) 1925864..1926586 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW953_RS09270 (NW953_09270) 1926579..1928036 - 1458 WP_258409259.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254769 WP_000031108.1 NZ_CP102975:c1923328-1923176 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT254769 WP_001251219.1 NZ_CP102975:c1923952-1923353 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References