Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2066241..2066755 Replicon chromosome
Accession NZ_CP102974
Organism Staphylococcus aureus strain 01-RR-86

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NW945_RS10065 Protein ID WP_000581792.1
Coordinates 2066241..2066450 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW945_RS10070 Protein ID WP_000138932.1
Coordinates 2066462..2066755 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW945_RS10045 (NW945_10045) 2061749..2063107 - 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW945_RS10050 (NW945_10050) 2063122..2064192 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NW945_RS10055 (NW945_10055) 2064510..2065712 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NW945_RS10060 (NW945_10060) 2065976..2066113 - 138 WP_000828354.1 Lmo0850 family protein -
NW945_RS10065 (NW945_10065) 2066241..2066450 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NW945_RS10070 (NW945_10070) 2066462..2066755 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW945_RS10075 (NW945_10075) 2066921..2068405 + 1485 WP_000571549.1 cardiolipin synthase -
NW945_RS10080 (NW945_10080) 2068433..2069080 + 648 WP_001187634.1 HD domain-containing protein -
NW945_RS10085 (NW945_10085) 2069752..2070624 - 873 WP_000725802.1 membrane protein insertase YidC -
NW945_RS10090 (NW945_10090) 2070710..2071351 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254761 WP_000581792.1 NZ_CP102974:c2066450-2066241 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254761 WP_000138932.1 NZ_CP102974:c2066755-2066462 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References