Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2046483..2047012 Replicon chromosome
Accession NZ_CP102974
Organism Staphylococcus aureus strain 01-RR-86

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW945_RS09975 Protein ID WP_000621175.1
Coordinates 2046483..2046845 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW945_RS09980 Protein ID WP_000948331.1
Coordinates 2046842..2047012 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW945_RS09955 (NW945_09955) 2043461..2044231 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
NW945_RS09960 (NW945_09960) 2044206..2044685 - 480 WP_001190829.1 anti-sigma B factor RsbW -
NW945_RS09965 (NW945_09965) 2044687..2045013 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW945_RS09970 (NW945_09970) 2045132..2046133 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW945_RS09975 (NW945_09975) 2046483..2046845 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW945_RS09980 (NW945_09980) 2046842..2047012 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW945_RS09985 (NW945_09985) 2047097..2048245 - 1149 WP_001281145.1 alanine racemase -
NW945_RS09990 (NW945_09990) 2048311..2048670 - 360 WP_000581200.1 holo-ACP synthase -
NW945_RS09995 (NW945_09995) 2048674..2049165 - 492 WP_001205910.1 PH domain-containing protein -
NW945_RS10000 (NW945_10000) 2049152..2050735 - 1584 WP_258414258.1 PH domain-containing protein -
NW945_RS10005 (NW945_10005) 2050728..2051207 - 480 WP_044290680.1 membrane protein -
NW945_RS10010 (NW945_10010) 2051416..2051976 - 561 WP_044290681.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254760 WP_000621175.1 NZ_CP102974:c2046845-2046483 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254760 WP_000948331.1 NZ_CP102974:c2047012-2046842 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References