Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tsbAT/-
Location 1885133..1885909 Replicon chromosome
Accession NZ_CP102974
Organism Staphylococcus aureus strain 01-RR-86

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW945_RS09050 Protein ID WP_000031108.1
Coordinates 1885133..1885285 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NW945_RS09055 Protein ID WP_001251224.1
Coordinates 1885310..1885909 (-) Length 200 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW945_RS09035 (NW945_09035) 1881579..1881974 - 396 WP_000901023.1 hypothetical protein -
NW945_RS09040 (NW945_09040) 1882509..1883270 - 762 WP_001066123.1 IS21-like element helper ATPase IstB -
NW945_RS09045 (NW945_09045) 1883263..1884555 - 1293 WP_029550026.1 IS21 family transposase -
NW945_RS09050 (NW945_09050) 1885133..1885285 - 153 WP_000031108.1 SAS053 family protein Toxin
NW945_RS09055 (NW945_09055) 1885310..1885909 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NW945_RS09060 (NW945_09060) 1886068..1886538 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW945_RS09065 (NW945_09065) 1886543..1887670 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
NW945_RS09070 (NW945_09070) 1887821..1888543 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW945_RS09075 (NW945_09075) 1888536..1889993 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1882509..1883273 764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(124-196)


Sequences


Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254759 WP_000031108.1 NZ_CP102974:c1885285-1885133 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp


Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT254759 WP_001251224.1 NZ_CP102974:c1885909-1885310 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB X5E2E6


Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References