Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2116375..2116889 Replicon chromosome
Accession NZ_CP102972
Organism Staphylococcus aureus strain 05-RR-90

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NW963_RS10440 Protein ID WP_000581792.1
Coordinates 2116375..2116584 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW963_RS10445 Protein ID WP_000138932.1
Coordinates 2116596..2116889 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW963_RS10420 (NW963_10415) 2111883..2113241 - 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW963_RS10425 (NW963_10420) 2113256..2114326 - 1071 WP_050968780.1 D-alanine--D-alanine ligase -
NW963_RS10430 (NW963_10425) 2114644..2115846 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NW963_RS10435 (NW963_10430) 2116110..2116247 - 138 WP_000828354.1 Lmo0850 family protein -
NW963_RS10440 (NW963_10435) 2116375..2116584 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NW963_RS10445 (NW963_10440) 2116596..2116889 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW963_RS10450 (NW963_10445) 2117055..2118539 + 1485 WP_000571549.1 cardiolipin synthase -
NW963_RS10455 (NW963_10450) 2118567..2119214 + 648 WP_001187629.1 HD domain-containing protein -
NW963_RS10460 (NW963_10455) 2119828..2120700 - 873 WP_000725802.1 membrane protein insertase YidC -
NW963_RS10465 (NW963_10460) 2120786..2121427 - 642 WP_258412245.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254750 WP_000581792.1 NZ_CP102972:c2116584-2116375 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254750 WP_000138932.1 NZ_CP102972:c2116889-2116596 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References