Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2096618..2097147 Replicon chromosome
Accession NZ_CP102972
Organism Staphylococcus aureus strain 05-RR-90

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW963_RS10350 Protein ID WP_000621175.1
Coordinates 2096618..2096980 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW963_RS10355 Protein ID WP_000948331.1
Coordinates 2096977..2097147 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW963_RS10330 (NW963_10325) 2093596..2094366 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
NW963_RS10335 (NW963_10330) 2094341..2094820 - 480 WP_001190829.1 anti-sigma B factor RsbW -
NW963_RS10340 (NW963_10335) 2094822..2095148 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW963_RS10345 (NW963_10340) 2095267..2096268 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW963_RS10350 (NW963_10345) 2096618..2096980 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW963_RS10355 (NW963_10350) 2096977..2097147 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW963_RS10360 (NW963_10355) 2097232..2098380 - 1149 WP_001281145.1 alanine racemase -
NW963_RS10365 (NW963_10360) 2098446..2098805 - 360 WP_000581197.1 holo-ACP synthase -
NW963_RS10370 (NW963_10365) 2098809..2099300 - 492 WP_001205912.1 PH domain-containing protein -
NW963_RS10375 (NW963_10370) 2099287..2100870 - 1584 WP_001294620.1 PH domain-containing protein -
NW963_RS10380 (NW963_10375) 2100863..2101342 - 480 WP_001287079.1 hypothetical protein -
NW963_RS10385 (NW963_10380) 2101551..2102111 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254749 WP_000621175.1 NZ_CP102972:c2096980-2096618 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254749 WP_000948331.1 NZ_CP102972:c2097147-2096977 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References