Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1897779..1898555 Replicon chromosome
Accession NZ_CP102972
Organism Staphylococcus aureus strain 05-RR-90

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW963_RS09090 Protein ID WP_000031108.1
Coordinates 1897779..1897931 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NW963_RS09095 Protein ID WP_001251224.1
Coordinates 1897956..1898555 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW963_RS09075 (NW963_09070) 1893982..1894803 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NW963_RS09080 (NW963_09075) 1895255..1896640 - 1386 WP_000116229.1 class II fumarate hydratase -
NW963_RS09085 (NW963_09080) 1896836..1897231 - 396 WP_000901023.1 hypothetical protein -
NW963_RS09090 (NW963_09085) 1897779..1897931 - 153 WP_000031108.1 SAS053 family protein Toxin
NW963_RS09095 (NW963_09090) 1897956..1898555 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NW963_RS09100 (NW963_09095) 1898714..1899184 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW963_RS09105 (NW963_09100) 1899189..1900316 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
NW963_RS09110 (NW963_09105) 1900468..1901190 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW963_RS09115 (NW963_09110) 1901183..1902640 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254748 WP_000031108.1 NZ_CP102972:c1897931-1897779 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT254748 WP_001251224.1 NZ_CP102972:c1898555-1897956 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References