Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2457631..2458154 Replicon chromosome
Accession NZ_CP102971
Organism Staphylococcus aureus strain 08-G-E

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NW975_RS12095 Protein ID WP_258412665.1
Coordinates 2457631..2457897 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag NW975_RS12100 Protein ID WP_000587617.1
Coordinates 2457897..2458154 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW975_RS12075 (NW975_12075) 2452936..2454123 - 1188 WP_000026189.1 MFS transporter -
NW975_RS12080 (NW975_12080) 2454519..2455295 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NW975_RS12085 (NW975_12085) 2455288..2455950 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
NW975_RS12090 (NW975_12090) 2456198..2457274 - 1077 WP_001076673.1 M42 family metallopeptidase -
NW975_RS12095 (NW975_12095) 2457631..2457897 - 267 WP_258412665.1 Txe/YoeB family addiction module toxin Toxin
NW975_RS12100 (NW975_12100) 2457897..2458154 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW975_RS12105 (NW975_12105) 2458514..2458969 + 456 WP_000732076.1 DUF1307 domain-containing protein -
NW975_RS12110 (NW975_12110) 2459137..2460714 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
NW975_RS12115 (NW975_12115) 2460909..2461658 + 750 WP_000072462.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(26-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10704.30 Da        Isoelectric Point: 10.1597

>T254746 WP_258412665.1 NZ_CP102971:c2457897-2457631 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHTYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT254746 WP_000587617.1 NZ_CP102971:c2458154-2457897 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References