Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2071452..2071966 Replicon chromosome
Accession NZ_CP102971
Organism Staphylococcus aureus strain 08-G-E

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NW975_RS10115 Protein ID WP_000581792.1
Coordinates 2071452..2071661 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW975_RS10120 Protein ID WP_000138932.1
Coordinates 2071673..2071966 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW975_RS10095 (NW975_10095) 2066960..2068318 - 1359 WP_258411762.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW975_RS10100 (NW975_10100) 2068333..2069403 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NW975_RS10105 (NW975_10105) 2069721..2070923 + 1203 WP_054190441.1 FtsW/RodA/SpoVE family cell cycle protein -
NW975_RS10110 (NW975_10110) 2071187..2071324 - 138 WP_000828354.1 Lmo0850 family protein -
NW975_RS10115 (NW975_10115) 2071452..2071661 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NW975_RS10120 (NW975_10120) 2071673..2071966 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW975_RS10125 (NW975_10125) 2072132..2073616 + 1485 WP_000571549.1 cardiolipin synthase -
NW975_RS10130 (NW975_10130) 2073644..2074291 + 648 WP_258411763.1 HD domain-containing protein -
NW975_RS10135 (NW975_10135) 2075105..2075977 - 873 WP_000725802.1 membrane protein insertase YidC -
NW975_RS10140 (NW975_10140) 2076063..2076704 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254742 WP_000581792.1 NZ_CP102971:c2071661-2071452 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254742 WP_000138932.1 NZ_CP102971:c2071966-2071673 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References